In addition, the current level of PGS screening precision is very good, but it is likely that it will continue to become even more accurate as different screening platforms evolve. Currently, many centers use Next Generation Sequencing (NGS) to screen parts of the embryos expressed DNA. Humans only express 1.5 to 3% of our entire DNA, while the other remaining DNA is used for regulation activities. Things like promoters, enhancers, silencer segments of DNA are in our non-expressed regions and the are what make us unique humans. So as PGS is able to screen more of (1) the expressed DNA and/or (2) non-expressed DNA, implantation failures with PGS embryos should hopefully decline further. Hope this helps!

As many colleagues have expressed the importance and accuracy of current PGS, having a chromosomally normal/balanced embryo does not guarantee its overall quality. Absolutely, most of the time when embryos are chromosomally normal, they tend to be of good quality. It is unfortunate, however, when somewhat poorly graded embryos come back as euploid (normal) and their trophectoderm layer is not viable enough to achieve good implantation. This unfortunately could be your case; whether the embryo did not implant at all, or did so minimally that a pregnancy test was negative (hCG produced by the trophectoderm was so low it was not able to be resulted as positive). This is another possibility on why a euploid embryo transfer resulted in a negative pregnancy test.